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Cavernous Malformation & Vascular Research

From molecular disease mechanisms to precision neurovascular treatment

Description

The Cavernous Malformation & Vascular Research Program investigates cerebral and spinal vascular malformations, with a particular focus on cerebral cavernous malformations.

Clinical neurosurgery, vascular neuroscience, molecular research, genetics and advanced imaging are integrated to improve our understanding of the development, progression and hemorrhagic mechanisms of vascular lesions.

The objective is to improve individualized risk assessment and to advance strategies for observation, surgical indication, microsurgical treatment and long-term follow-up.

Key Research Areas

Investigation of the natural history, hemorrhage risk and therapeutic strategies for superficial and deep-seated cavernous malformations, including brainstem cavernous malformations.
Research into cellular signaling pathways, genetic alterations and biological mechanisms contributing to the formation, progression and hemorrhagic tendency of cavernous malformations.
Advancement of microsurgical strategies for complex vascular lesions with particular emphasis on functional preservation.
Use of high-resolution MRI and susceptibility-sensitive imaging techniques to characterize vascular lesions, previous hemorrhage and longitudinal changes.
Translation of molecular and experimental discoveries into clinically relevant approaches for diagnosis, risk assessment and treatment.
Systematic analysis of neurological outcomes, risk of recurrent hemorrhage, functional recovery and long-term disease trajectories.